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Retrosynthetic analysis is the cornerstone of organic synthesis, allowing scientists to simplify complex target molecules
into small fragments by disconnecting bonds. This review details basic concepts and common simplifying methods that
scientists used in the retrosynthetic analysis. By using straightforward language and rich examples, the beginners can gain
an overall understanding of retrosynthetic analysis and start to use techniques that they learned in this review to design
synthetic pathways on paper. The last part provides a possible synthetic pathway for dihydrolucilactaene, a new potent
drug for malaria, using the simplifying methods mentioned above.
Luyu Li,Jiawei Yu, andYang Zhao
"Introduction to retrosynthetic analysis: basic concepts, simplification methods, and application", Proc. SPIE 12326, 2nd International Conference on Materials Chemistry and Environmental Engineering (CONF-MCEE 2022), 123260F (5 August 2022); https://doi.org/10.1117/12.2646165
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Luyu Li, Jiawei Yu, Yang Zhao, "Introduction to retrosynthetic analysis: basic concepts, simplification methods, and application," Proc. SPIE 12326, 2nd International Conference on Materials Chemistry and Environmental Engineering (CONF-MCEE 2022), 123260F (5 August 2022); https://doi.org/10.1117/12.2646165