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17 March 2023 Temporal optical filtering: finding a needle in the Raman haystack
Terumasa Ito, Fumiaki Matsuoka, Kazuhiko Misawa
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Proceedings Volume 12357, Visualizing and Quantifying Drug Distribution in Tissue VII; 123570E (2023) https://doi.org/10.1117/12.2651050
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Stimulated Raman scattering (SRS) offers high sensitivity to monitor low-concentration drugs in real time. However, the "needle" of a drug signal at millimolar concentrations is hidden in the "haystack" of tissue background Raman signals, which practically limits the specificity of the drug measurements. Here, we compare two promising solutions, namely frequency-modulated SRS (FM-SRS) and time-resolved phase-modulated SRS (PM-SRS). We show that the temporal response of FM-SRS is a simple sinusoidal function and its specificity must be compromised. However, the time-resolved PM-SRS with shaped probe pulses provides temporal high-pass filtering with steep cutoff characteristics, enabling higher specificity in the drug measurement.
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Terumasa Ito, Fumiaki Matsuoka, and Kazuhiko Misawa "Temporal optical filtering: finding a needle in the Raman haystack", Proc. SPIE 12357, Visualizing and Quantifying Drug Distribution in Tissue VII, 123570E (17 March 2023); https://doi.org/10.1117/12.2651050
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KEYWORDS
Raman spectroscopy
Optical filters
Tissues
Imaging spectroscopy
Linear filtering
Microscopy
Molecules
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