Monitoring neoadjuvant chemotherapy through time domain diffuse optical spectroscopy: preliminary clinical results

Nikhitha Mule; Giulia Maffeis; Carolina Santangelo; Rinaldo Cubeddu; Antonio Pifferi; Pietro Panizza; Paola Taroni

doi:10.1117/12.2648865

7 March 2023 Monitoring neoadjuvant chemotherapy through time domain diffuse optical spectroscopy: preliminary clinical results

Nikhitha Mule, Giulia Maffeis, Carolina Santangelo, Rinaldo Cubeddu, Antonio Pifferi, Pietro Panizza, Paola Taroni

Author Affiliations +

Proceedings Volume 12376, Optical Tomography and Spectroscopy of Tissue XV; 123760L (2023) https://doi.org/10.1117/12.2648865
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

The purpose of this clinical study is to monitor NeoAdjuvant Chemotherapy through time domain Diffuse Optical Spectroscopy, correlate the optical results with conventional imaging techniques and pathological response and eventually predict the efficacy of NAC in breast cancer patients. Our seven wavelength (635 -1060 nm) optical mammograph is used to perform non-invasive measurements on patients undergoing NAC in this study. The broad spectral range helps us to fully analyze tissue composition, that includes hemoglobin, water lipids and collagen concentration, to track the tumor response during the course of the therapy. In this paper, we present the preliminary results of five patients.

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Citation Download Citation

Nikhitha Mule, Giulia Maffeis, Carolina Santangelo, Rinaldo Cubeddu, Antonio Pifferi, Pietro Panizza, and Paola Taroni "Monitoring neoadjuvant chemotherapy through time domain diffuse optical spectroscopy: preliminary clinical results", Proc. SPIE 12376, Optical Tomography and Spectroscopy of Tissue XV, 123760L (7 March 2023); https://doi.org/10.1117/12.2648865

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