Transurethral photoacoustic and ultrasonic endoscopic probe developed for bladder cancer diagnosis

Jin Young Youm; KiSik Kim; Eun Hye Lee; Oleksandra Gulenko; Minjae Kim; Bo Hyun Yoon; Minji Jeon; Tae Hyo Kim; Yun-Sok Ha; Joon-Mo Yang

doi:10.1117/12.2651028

9 March 2023 Transurethral photoacoustic and ultrasonic endoscopic probe developed for bladder cancer diagnosis

Jin Young Youm, KiSik Kim, Eun Hye Lee, Oleksandra Gulenko, Minjae Kim, Bo Hyun Yoon, Minji Jeon, Tae Hyo Kim, Yun-Sok Ha, Joon-Mo Yang

Author Affiliations +

Proceedings Volume 12379, Photons Plus Ultrasound: Imaging and Sensing 2023; 1237904 (2023) https://doi.org/10.1117/12.2651028
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

The minimally invasive application of photoacoustic (optoacoustic) tomography (PAT) has been mainly focused on gastrointestinal endoscopy and the imaging of cardiovascular and reproductive systems, such as the uterus, ovaries, and prostate, in relation to the diagnosis of atherosclerotic plaques (e.g., in coronary arteries) and reproductive cancers. However, the miniature probe technology involved could also make a considerable contribution to the diagnosis and post-treatment follow-ups of urinary diseases. PAT can provide a variety of anatomical, functional, and molecular information that is not producible with conventional imaging methods, such as MRI and ultrasound. Among the related clinical issues, the development of a new diagnostic paradigm for the early detection of bladder cancer is urgently needed, because it is known to be very aggressive and lethal if found after stage 2 (T2). In this study, we developed a transurethral photoacoustic and ultrasonic endoscopic probe with an outer diameter of 2.8 mm to contribute to the early diagnosis of bladder cancer in clinical urology. From a live rabbit, we successfully acquired the first high-resolution 3D vasculature map of more than 50% of the bladder wall, which we believe is a completely new type of image information never acquired before from a vertebrate urinary system.

Conference Presentation

Citation Download Citation

Jin Young Youm, KiSik Kim, Eun Hye Lee, Oleksandra Gulenko, Minjae Kim, Bo Hyun Yoon, Minji Jeon, Tae Hyo Kim, Yun-Sok Ha, and Joon-Mo Yang "Transurethral photoacoustic and ultrasonic endoscopic probe developed for bladder cancer diagnosis", Proc. SPIE 12379, Photons Plus Ultrasound: Imaging and Sensing 2023, 1237904 (9 March 2023); https://doi.org/10.1117/12.2651028

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