Light source-detector pair positioning to optimize tagging efficiency of focused ultrasound-modulated photons in a backward detection mode

Mohammadreza Omidali; Ali Mardanshahi; Zuomin Zhao; Deepak Sonker; Alexander Bykov; Teemu Myllylä

doi:10.1117/12.2650594

9 March 2023 Light source-detector pair positioning to optimize tagging efficiency of focused ultrasound-modulated photons in a backward detection mode

Mohammadreza Omidali, Ali Mardanshahi, Zuomin Zhao, Deepak Sonker, Alexander Bykov, Teemu Myllylä

Author Affiliations +

Proceedings Volume 12379, Photons Plus Ultrasound: Imaging and Sensing 2023; 123791N (2023) https://doi.org/10.1117/12.2650594
Event: SPIE BiOS, 2023, San Francisco, California, United States

Conference Poster

Abstract

Focusing Ultrasound (FUS) can be used to modulate diffusing light in tissue. In this method, diffused photons are modulated in the ultrasound focus area. Detecting these FUS modulated (or tagged) photons can provide spatially accurate information from the focus area. However, probably the biggest challenge in this method is to enable sufficient tagging photons since most of the illuminated and detected photons do not propagate thru the FUS target area resulting in a low number of tagged photons when compared to the background unmodulated light. Therefore, current applications utilizing such hybrid technique are still limited. Our study aims to optimize illumination and detection of photons that propagate through a FUS target area by adjusting the relative position and angle of a light source-detector pair. For the simulations, the K-wave toolbox was utilized to calculate the nonlinear acoustic pressure field in the discretized numerical model from the FUS source. Furthermore, light propagation in the model is simulated using an open-source Monte Carlo algorithm. The model design is a backward detection mode which is suitable for direct application to the human body.

Citation Download Citation

Mohammadreza Omidali, Ali Mardanshahi, Zuomin Zhao, Deepak Sonker, Alexander Bykov, and Teemu Myllylä "Light source-detector pair positioning to optimize tagging efficiency of focused ultrasound-modulated photons in a backward detection mode", Proc. SPIE 12379, Photons Plus Ultrasound: Imaging and Sensing 2023, 123791N (9 March 2023); https://doi.org/10.1117/12.2650594

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available