Immunological functions of a biopolymer in enhancing laser phototherapy (Conference Presentation)

Kaili Liu; Ashley R. Hoover; Coline Furrer; Trisha I. Valerio; Wei R Chen

doi:10.1117/12.2651984

14 March 2023 Immunological functions of a biopolymer in enhancing laser phototherapy (Conference Presentation)

Kaili Liu, Ashley R. Hoover, Coline Furrer, Trisha I. Valerio, Wei R Chen

Proceedings Volume 12380, Biophotonics and Immune Responses XVIII; 1238003 (2023) https://doi.org/10.1117/12.2651984
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

A novel biopolymer, N-dihydrogalactochitosan (GC), is developed for inducing immune responses. GC stimulates innate and adaptive antitumor and antiviral immunities. In this study, we investigated the mechanism of GC-induced immune responses through in vitro and in vivo studies. We find that GC drives type I IFN production and IFN responses in antigen presenting cells (APCs). Furthermore, GC drives alternative activation of STING leading to inflammatory cell death that enhances dendritic cell (DC) activation. In vivo, GC induced a potent response of type I IFN and upregulated genes associated with STING signaling within the tumor microenvironment (TME). Because of its potent immunological stimulation ability and its unique mechanism in inducing the immune responses, GC has been used in combination with laser photothermal (PTT) for the treatment of cancers. We find that PTT+GC induced specific modulation of immune cells, positively corresponding to long-term survival of cancer patient.

Conference Presentation

Citation Download Citation

Kaili Liu, Ashley R. Hoover, Coline Furrer, Trisha I. Valerio, and Wei R Chen "Immunological functions of a biopolymer in enhancing laser phototherapy (Conference Presentation)", Proc. SPIE 12380, Biophotonics and Immune Responses XVIII, 1238003 (14 March 2023); https://doi.org/10.1117/12.2651984

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available