Label-free characterization of oxidative stress impact on Drosophila brain elasticity using combined Brillouin-Raman spectroscopy

Vsevolod Cheburkanov; Jace Willis; Vladislav Yakovlev

doi:10.1117/12.2650937

16 March 2023 Label-free characterization of oxidative stress impact on Drosophila brain elasticity using combined Brillouin-Raman spectroscopy

Vsevolod Cheburkanov, Jace Willis, Vladislav Yakovlev

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Proceedings Volume 12391, Label-free Biomedical Imaging and Sensing (LBIS) 2023; 123910U (2023) https://doi.org/10.1117/12.2650937
Event: SPIE BiOS, 2023, San Francisco, California, United States

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Abstract

Neurodegenerative diseases are currently among the most common causes for low quality of life among US population. In addition to that, disabilities caused by neurodegenerative diseases, negatively impact economy by causing early workforce retirement. Existing human models of such conditions are hard to replicate and describe due to the wide array of factors influencing the progression and morphology of the disease. Recent studies suggest application of photodynamically induced oxidative stress in drosophila model as a viable trigger to neurodegenerative conditions. We hypothesize that neural degradation is accompanied by significant changes in brain chemistry and biomechanics. This preliminary study focuses on investigation of correlation between drosophila brain elasticity and induced oxidative stress using combined Brillouin-Raman spectroscopy as a label-free method of elasticity measurement.

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Vsevolod Cheburkanov, Jace Willis, and Vladislav Yakovlev "Label-free characterization of oxidative stress impact on Drosophila brain elasticity using combined Brillouin-Raman spectroscopy", Proc. SPIE 12391, Label-free Biomedical Imaging and Sensing (LBIS) 2023, 123910U (16 March 2023); https://doi.org/10.1117/12.2650937

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