Widefield infrared photothermal imaging and spectroscopy

Kirill Kniazev; Evgenii Zaitsev; Loc Ngo; Zhuoming Zhang; Masaru Kuno

doi:10.1117/12.2648082

15 March 2023 Widefield infrared photothermal imaging and spectroscopy

Kirill Kniazev, Evgenii Zaitsev, Loc Ngo, Zhuoming Zhang, Masaru Kuno

Proceedings Volume 12392, Advanced Chemical Microscopy for Life Science and Translational Medicine 2023; 1239203 (2023) https://doi.org/10.1117/12.2648082
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Infrared photothermal heterodyne imaging (IR-PHI) is an ultrasensitive technique capable of achieving super-resolution chemical and morphological characterization of specimens via absorption of mid-infrared light. While early iterations of IR-PHI have involved point-by-point raster-scanning, here, we introduce a widefield modality to IR-PHI that utilizes ns-timescale infrared pump pulses synchronized to an ultrafast complementary metal-oxide-semiconductor camera to parallelize data acquisition. A 300-fold decrease in image acquisition time is realized, falling from 20 minutes to four seconds.

Conference Presentation

Citation Download Citation

Kirill Kniazev, Evgenii Zaitsev, Loc Ngo, Zhuoming Zhang, and Masaru Kuno "Widefield infrared photothermal imaging and spectroscopy", Proc. SPIE 12392, Advanced Chemical Microscopy for Life Science and Translational Medicine 2023, 1239203 (15 March 2023); https://doi.org/10.1117/12.2648082

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