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8 March 2023 Towards quantum-enhanced Raman spectroscopy for bioimaging applications
Mikael Lassen, Oleksii Ilchenko, Ulrik Andersen, Michael Fritzsche, Maria Chekhova, Mark Kriegsmann, Aleksander Rebane
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Proceedings Volume 12447, Quantum Sensing, Imaging, and Precision Metrology; 124471E (2023) https://doi.org/10.1117/12.2646648
Event: SPIE Quantum West, 2023, San Francisco, California, United States
Abstract
In the QuantERA project QURAMAN (Quantum Raman) are we aiming for a combination of breakthroughs and improvements of existing components and already existing setups for building a commercial quantum Raman microscope. By combining the project partners’ expertise and skills in quantum optics, nonlinear optics, Raman spectroscopy and medical device design we will develop the next-generation Raman microscope for bio-imaging with quantum-enhanced sensitivity. The background knowledge and idea behind the QuRAMAN project is described in our recent publications (Optica 7, 470-475 (2020)). Where we have demonstrated that the use of continuous wave (CW) squeezed light can improve the SNR of weak Raman signals. However, to beat the performance of state-of-the-art SRS microscopes by means of squeezed light, one must employ amplitude squeezed picosecond pulses in a strongly focusing configuration (using an objective with a numerical aperture above unity). This will enable the imaging of weak Raman features and will push the Raman technology beyond the state of the art by applying pulsed amplitude squeezed light for signal enhancement.
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Mikael Lassen, Oleksii Ilchenko, Ulrik Andersen, Michael Fritzsche, Maria Chekhova, Mark Kriegsmann, and Aleksander Rebane "Towards quantum-enhanced Raman spectroscopy for bioimaging applications", Proc. SPIE 12447, Quantum Sensing, Imaging, and Precision Metrology, 124471E (8 March 2023); https://doi.org/10.1117/12.2646648
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KEYWORDS
Lung cancer
Diagnostics
Picosecond phenomena
Quantum amplitude
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