Study on glomerular transforming growth factor level on renal fibrosis by Centella asiatica

Tianyi Ma

doi:10.1117/12.2660651

6 December 2022 Study on glomerular transforming growth factor level on renal fibrosis by Centella asiatica

Tianyi Ma

Proceedings Volume 12458, International Conference on Biomedical and Intelligent Systems (IC-BIS 2022); 1245803 (2022) https://doi.org/10.1117/12.2660651
Event: International Conference on Biomedical and Intelligent Systems, 2022, Chengdu, China

Abstract

In this study, 48 rat models were established and randomly divided into experimental group (n=36) and control group (n=12). The experimental group was further divided into low-dose group, middle-dose group and high-dose group (n=12/group). the levels of transforming growth factor (TGF-β) and vascular endothelial growth factor(VEGF) were detected by enzyme-linked immunosorbent assay (ELISA) at 6 weeks,12 weeks and 18 weeks, respectively, which proved that Centella asiatica can inhibit renal tissue cytokines and extracellular matrix (ECM) produced. Compared with the control group, the level of TGF-β and VEGF in the kidney tissue of the rats in the model group was significantly increased. Compared with the model group, the level of TGF-β and VEGF in the kidney tissue of the rats in the Centella asiatica group was significantly decreased. It provides a theoretical basis for the effect of Centella asiatica on inhibiting renal fibrosis.

Citation Download Citation

Tianyi Ma "Study on glomerular transforming growth factor level on renal fibrosis by Centella asiatica", Proc. SPIE 12458, International Conference on Biomedical and Intelligent Systems (IC-BIS 2022), 1245803 (6 December 2022); https://doi.org/10.1117/12.2660651

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