Applications of atomic force microscope in disease detection

Ziying Feng

doi:10.1117/12.2660368

6 December 2022 Applications of atomic force microscope in disease detection

Ziying Feng

Proceedings Volume 12458, International Conference on Biomedical and Intelligent Systems (IC-BIS 2022); 1245827 (2022) https://doi.org/10.1117/12.2660368
Event: International Conference on Biomedical and Intelligent Systems, 2022, Chengdu, China

Abstract

Atomic force microscope (AFM) provides a number of significant benefits, including ultrahigh imaging resolution, a compact and non-destructive sample preparation technique, and the ability to detect materials in real time, among others. In biological and medical disciplines, AFM has been used to evaluate a variety of physical and chemical parameters, such as cell stiffness, average roughness of cell surfaces, and surface composition. The data are used to assess whether or not people have a certain disease, particularly cancer. Xu studied cellular migratory and invasiveness potential using cell surface stiffness as a biomarker. Guo used average cell surface roughness to reconstruct the dynamic changes in endothelial cell membrane structure that occur during diabetes. Under the AFM basic mode and the AM-FM visco-elastic mapping mode, González-Dominguez discovered the HIV protein capsid inside the lipid membrane. These polls present a rosy picture of medical treatment, particularly in terms of illness diagnosis.

Citation Download Citation

Ziying Feng "Applications of atomic force microscope in disease detection", Proc. SPIE 12458, International Conference on Biomedical and Intelligent Systems (IC-BIS 2022), 1245827 (6 December 2022); https://doi.org/10.1117/12.2660368

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