Optical fiber biosensor with enhanced fluorescence collection

Victoria Esteso; Pietro Lombardi; Francesco Chiavaioli; Prosenjit Majumder; Maja Colautti; Steffen Howitz; Paolo Cecchi; Francesco Baldini; Costanza Toninelli; Ambra Giannetti

doi:10.1117/12.2668897

31 May 2023 Optical fiber biosensor with enhanced fluorescence collection

Victoria Esteso, Pietro Lombardi, Francesco Chiavaioli, Prosenjit Majumder, Maja Colautti, Steffen Howitz, Paolo Cecchi, Francesco Baldini, Costanza Toninelli, Ambra Giannetti

Author Affiliations +

Proceedings Volume 12572, Optical Sensors 2023; 125721Q (2023) https://doi.org/10.1117/12.2668897
Event: SPIE Optics + Optoelectronics, 2023, Prague, Czech Republic

Conference Poster

Abstract

A lens-less optical fiber designed for enhanced-fluorescence biosensor applications is presented. In order to obtain the enhanced sensor performances, two elements are essential: a planar antenna that redirects fluorescence emission into a narrow cone and an automated fiber-based optical system for multi-spot analysis. In particular, the potential early diagnosis of sepsis via C-reactive protein (CRP) detection is here demonstrated, reaching a limit of detection of 1.5 ng/mL), which is in the clinical range of interest for such biomarker. Upon the combination with other sepsis biomarkers, the presented sensor can become relevant for the early diagnosis of sepsis. These results validate the developed prototype as a simple, affordable, easy-to-operate, plug&play device with fast turnaround times, compatible with standardized micro-well arrays, and potentially suitable for POC applications with respect to the diagnosis of sepsis. It is also suitable for implementation with other biomarkers and liquid environments.

Citation Download Citation

Victoria Esteso, Pietro Lombardi, Francesco Chiavaioli, Prosenjit Majumder, Maja Colautti, Steffen Howitz, Paolo Cecchi, Francesco Baldini, Costanza Toninelli, and Ambra Giannetti "Optical fiber biosensor with enhanced fluorescence collection", Proc. SPIE 12572, Optical Sensors 2023, 125721Q (31 May 2023); https://doi.org/10.1117/12.2668897

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