Development and application of 4D light-field and quantum imaging technologies

Takuma Sugi

doi:10.1117/12.3008168

20 September 2023 Development and application of 4D light-field and quantum imaging technologies

Takuma Sugi

Proceedings Volume 12608, Biomedical Imaging and Sensing Conference; 126081P (2023) https://doi.org/10.1117/12.3008168
Event: Optics and Photonics International Congress, 2023, Yokohama, Japan

Abstract

Behavior is a consequence of computation in a neural circuit composed of massive millisecond neural firings that undergo in 4D space. We recently found that the nematode Caenorhabditis elegans exhibits collective pattern formations. To examine the neural computation mechanism in this collective behavior, we are developing a new light-field microscopy. Light-field microscopy is a computational imaging technology that enables scan-less, single-shot acquisition of a 3D volumetric image by postprocessing 2D camera snapshots recorded via a microlens array. Here, we show C. elegans collective behavior and high-resolution light-field microscopy. We performed single-shot 4D brain-wide imaging of a freely behaving C. elegans with high temporal resolution and 3D volumetric imaging of mouse hippocampus amyloid plaques. Finally, we also combined high-resolution light-field microscopy with a quantum sensor, and demonstrated an ultrasensitive 4D physical parameter sensing in Hela cells and in vivo.

Citation Download Citation

Takuma Sugi "Development and application of 4D light-field and quantum imaging technologies", Proc. SPIE 12608, Biomedical Imaging and Sensing Conference, 126081P (20 September 2023); https://doi.org/10.1117/12.3008168

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