An overview of stem cell-based therapy towards the treatment of Alzheimer’s disease

San-Chi Chen

doi:10.1117/12.2669040

24 March 2023 An overview of stem cell-based therapy towards the treatment of Alzheimer’s disease

San-Chi Chen

Proceedings Volume 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022); 1261136 (2023) https://doi.org/10.1117/12.2669040
Event: International Conference on Biological Engineering and Medical Science (ICBioMed2022), 2022, Oxford, United Kingdom

Abstract

The classic pharmacological approach toward Alzheimer’s disease treatment uses acetylcholinesterase inhibitors (AChEIs), where patients’ behavior and cognitive symptoms can be treated. However, the pharmacological approaches available can only relieve patients’ symptoms to some extent instead of acting as a cure. With the recent advancements in regenerative medicine, extensive pre-clinical studies have been conducted to test if stem cell therapy can be a cure for Alzheimer’s disease. The stem cell type being investigated through the treatment of Alzheimer’s disease includes embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), mesenchymal stem cells (MSCs), and neural stem cells (NSCs). This review briefly introduces the causes and pharmacological approach to Alzheimer’s disease, highlights some of the critical results reported from the pre-clinical studies and discusses the challenges associated with each type of cell when used as a source for conducting stem cell therapy for Alzheimer’s disease. Although preclinical studies have proved relevant mediated effects to Alzheimer’s disease can be induced by stem cell therapy.

Citation Download Citation

San-Chi Chen "An overview of stem cell-based therapy towards the treatment of Alzheimer’s disease", Proc. SPIE 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022), 1261136 (24 March 2023); https://doi.org/10.1117/12.2669040

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