Evaluation of neoadjuvant chemotherapy-induced changes in contralateral healthy breast tissue through diffuse optical spectroscopy

Nikhitha Mule; Giulia Maffeis; Carolina Santangelo; Rinaldo Cubeddu; Antonio Pifferi; Pietro Panizza; Paola Taroni

doi:10.1117/12.2670661

9 August 2023 Evaluation of neoadjuvant chemotherapy-induced changes in contralateral healthy breast tissue through diffuse optical spectroscopy

Nikhitha Mule, Giulia Maffeis, Carolina Santangelo, Rinaldo Cubeddu, Antonio Pifferi, Pietro Panizza, Paola Taroni

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Proceedings Volume 12628, Diffuse Optical Spectroscopy and Imaging IX; 1262808 (2023) https://doi.org/10.1117/12.2670661
Event: European Conferences on Biomedical Optics, 2023, Munich, Germany

Abstract

This study aims at evaluating the effect of NeoAdjuvant Chemotherapy (NAC) on the contralateral tumor-free breast tissue through time domain diffuse optical spectroscopy. The breast tissue composition consisting of hemoglobin, water, lipid, and collagen concentrations is quantitatively derived using our seven-wavelength (635-1060 nm) optical mammograph. Preliminary analysis of ten patients' data shows compositional changes occurring in the non-tumor breast in addition to the tumor breast. This includes reduction in breast density and components’ concentrations through the course of the therapy. The final goal is to eventually identify if there is a correlation of these effects with pathological complete response.

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Nikhitha Mule, Giulia Maffeis, Carolina Santangelo, Rinaldo Cubeddu, Antonio Pifferi, Pietro Panizza, and Paola Taroni "Evaluation of neoadjuvant chemotherapy-induced changes in contralateral healthy breast tissue through diffuse optical spectroscopy", Proc. SPIE 12628, Diffuse Optical Spectroscopy and Imaging IX, 1262808 (9 August 2023); https://doi.org/10.1117/12.2670661

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KEYWORDS

Breast

Tissues

Breast cancer

Chemotherapy

Diffuse optical spectroscopy

Tumors

Mammography

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