Short and long-term photostability of 3D printed fluorescent phantoms for near-infrared diffuse optical imaging

Sandra Schädel-Ebner; Ole Hirsch; Thomas Gladytz; Dirk Gutkelch; Kai Licha; Jörn Berger; Dirk Grosenick

doi:10.1117/12.2670658

9 August 2023 Short and long-term photostability of 3D printed fluorescent phantoms for near-infrared diffuse optical imaging

Sandra Schädel-Ebner, Ole Hirsch, Thomas Gladytz, Dirk Gutkelch, Kai Licha, Jörn Berger, Dirk Grosenick

Author Affiliations +

Proceedings Volume 12628, Diffuse Optical Spectroscopy and Imaging IX; 126281A (2023) https://doi.org/10.1117/12.2670658
Event: European Conferences on Biomedical Optics, 2023, Munich, Germany

Abstract

We have successfully printed an anatomically shaped hand model with properties similar to in vivo investigations with a fluorescence hand imager using indocyanine green (ICG). By adding the fluorescent dye Lumogen IR 765, titanium dioxide powder and black ink to a 3D printing methacrylate photopolymer we realized phantoms with physiologically relevant absorption and reduced scattering coefficients as well as fluorescence properties similar to the widely applied contrast agent ICG. The phantoms show an excellent long-term photostability making them well suited for device performance monitoring and comparison. In contrast, fluorescence of phantoms printed with ICG continuously decreases over time.

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Sandra Schädel-Ebner, Ole Hirsch, Thomas Gladytz, Dirk Gutkelch, Kai Licha, Jörn Berger, and Dirk Grosenick "Short and long-term photostability of 3D printed fluorescent phantoms for near-infrared diffuse optical imaging", Proc. SPIE 12628, Diffuse Optical Spectroscopy and Imaging IX, 126281A (9 August 2023); https://doi.org/10.1117/12.2670658

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KEYWORDS

3D printing

3D image processing

Diffuse optical imaging

Dyes

Fluorescence

Diseases and disorders

Fluorescence imaging

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