Utilizing a ten million frames-per-second camera to investigate mechanisms responsible for laser pulse-induced reflectivity modulations in photoacoustic remote sensing

Nathaniel J. M. Haven; Matthew T. Martell; Haoyang Li; James D. Hogan; Roger J. Zemp

doi:10.1117/12.2670970

11 August 2023 Utilizing a ten million frames-per-second camera to investigate mechanisms responsible for laser pulse-induced reflectivity modulations in photoacoustic remote sensing

Nathaniel J. M. Haven, Matthew T. Martell, Haoyang Li, James D. Hogan, Roger J. Zemp

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Proceedings Volume 12631, Opto-Acoustic Methods and Applications in Biophotonics VI; 1263103 (2023) https://doi.org/10.1117/12.2670970
Event: European Conferences on Biomedical Optics, 2023, Munich, Germany

Abstract

Photoacoustic remote sensing has been recently developed as an all-optical, non-contact, and label-free imaging modality capable of imaging a variety of endogenous contrast agents through the detection of reflectivity modulations. Initial work described an elasto-optic refractive index perturbation model to explain reflectivity modulations observed, however, in practice the magnitude of these reflectivity modulations has been found to be orders of magnitude smaller than those typically observed experimentally. In this report we utilize a ten million frames-per-second camera to further investigate these reflectivity modulations, while also exploring other potential mechanisms of laser pulse-induced reflectivity modulations. Laser-induced motion is demonstrated both laterally for gold wires suspended and submerged in air and water, respectively, and carbon fibers submerged in water, and axial motion is observed in gold wires submerged in a depth gradient of intralipid solution. This laser-induced sample motion is anticipated to cause reflectivity modulations local to the interrogation beam profile in microscopy set-ups. Non-motion-based maximum intensity modulations of 3% are also observed in gold wires submerged in water, indicating the presence of the originally predicted reflectivity modulations. Overall, these observations are important as they provide a widefield view of laser-pulse interactions unavailable in previous point scanning-based photoacoustic remote sensing microscopy configurations, where observed mechanisms occur on time-scales orders of magnitude faster than equivalent field of view point scanning capabilities.

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Nathaniel J. M. Haven, Matthew T. Martell, Haoyang Li, James D. Hogan, and Roger J. Zemp "Utilizing a ten million frames-per-second camera to investigate mechanisms responsible for laser pulse-induced reflectivity modulations in photoacoustic remote sensing", Proc. SPIE 12631, Opto-Acoustic Methods and Applications in Biophotonics VI, 1263103 (11 August 2023); https://doi.org/10.1117/12.2670970

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KEYWORDS

Modulation

Photoacoustic spectroscopy

Remote sensing

Cameras

Gold

Water

Microscopy

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