Melanin migration in retinitis pigmentosa evaluated by ultra-wide-field polarization diversity optical coherence tomography

Yusi Miao; Shuibin Ni; Jun Song; Yifan Jian; Myeong Jin Ju

doi:10.1117/12.2670622

11 August 2023 Melanin migration in retinitis pigmentosa evaluated by ultra-wide-field polarization diversity optical coherence tomography

Yusi Miao, Shuibin Ni, Jun Song, Yifan Jian, Myeong Jin Ju

Author Affiliations +

Proceedings Volume 12632, Optical Coherence Imaging Techniques and Imaging in Scattering Media V; 1263206 (2023) https://doi.org/10.1117/12.2670622
Event: European Conferences on Biomedical Optics, 2023, Munich, Germany

Abstract

Our research investigates retinal pigmentary abnormalities in Retinitis Pigmentosa (RP) patients using ultra-wide-field high-speed Polarization Diversity Optical Coherence Tomography (PD-OCT) in a clinical setting. To account for the retinal curvature in the wide field of view, adaptive kernel-based spatial averaging is employed for Degree-of-Polarization-Uniformity (DOPU) contrast formation with two complex OCT signals from two orthogonal polarization channels. 20 patients diagnosed with RP were recruited for this study and imaged with PD-OCT. Then, the melanin distribution images from PD-OCT were compared to standard multimodal imaging techniques, including intensity-based OCT, fundus photography, and short-wavelength fundus autofluorescence images. Wide-field PD-OCT imaging technique presented in this study was capable of precisely assessing melanin-related changes in RP over a large field of view and monitoring the disease progression. As a next step, we are investigating the correlation of specific genetic mutations in RP patients with specific clinical presentations and disease progression rates as assessed by the quantitative measurements in PD-OCT. The clinical findings will be presented during the conference.

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Yusi Miao, Shuibin Ni, Jun Song, Yifan Jian, and Myeong Jin Ju "Melanin migration in retinitis pigmentosa evaluated by ultra-wide-field polarization diversity optical coherence tomography", Proc. SPIE 12632, Optical Coherence Imaging Techniques and Imaging in Scattering Media V, 1263206 (11 August 2023); https://doi.org/10.1117/12.2670622

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KEYWORDS

Optical coherence tomography

Polarization

Imaging systems

Diseases and disorders

Genetics

Multimodal imaging

Photography

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