Plasmonic metasurfaces for enhanced spectrochemical tissue imaging

Samir Rosas; Keegan A. Schoeller; Edward Chang; Hongyan Mei; Mikhail A. Kats; Kevin W. Eliceiri; Xinyu Zhao; Filiz Yesilkoy

doi:10.1117/12.2676281

3 October 2023 Plasmonic metasurfaces for enhanced spectrochemical tissue imaging

Samir Rosas, Keegan A. Schoeller, Edward Chang, Hongyan Mei, Mikhail A. Kats, Kevin W. Eliceiri, Xinyu Zhao, Filiz Yesilkoy

Author Affiliations +

Proceedings Volume 12654, Enhanced Spectroscopies and Nanoimaging 2023; 1265404 (2023) https://doi.org/10.1117/12.2676281
Event: SPIE Nanoscience + Engineering, 2023, San Diego, California, United States

Abstract

Label-free and nondestructive mid-infrared (MIR) vibrational hyperspectral imaging has emerged as a valuable ex-vivo tool for biomedical tissue analysis. However, due to the chemically complex and heterogeneous composition of tissue specimens, the analytical performance of conventional MIR spectral histopathology is limited. We introduce an innovative MIR spectrochemical tissue imaging modality that uses plasmonic metasurfaces to support strong surface-localized electromagnetic fields, enabling the capture of quantitative molecular maps of large-area brain tissue sections. Our surface-enhanced chemical imaging method has broad potential applications in both translational biomedical research and diagnostic clinical histopathology.

Conference Presentation

(2023) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Samir Rosas, Keegan A. Schoeller, Edward Chang, Hongyan Mei, Mikhail A. Kats, Kevin W. Eliceiri, Xinyu Zhao, and Filiz Yesilkoy "Plasmonic metasurfaces for enhanced spectrochemical tissue imaging", Proc. SPIE 12654, Enhanced Spectroscopies and Nanoimaging 2023, 1265404 (3 October 2023); https://doi.org/10.1117/12.2676281

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