Full assessment of in-stent restenosis and associated inflammation based on the integrated OCT-NIRF-US intravascular system

Zhuoquan Chen; Bing Wang; Ruiming Kong; Yuting Song; Dongqing Shang; Zeping Gao; Teng Ma

doi:10.1117/12.2687443

27 November 2023 Full assessment of in-stent restenosis and associated inflammation based on the integrated OCT-NIRF-US intravascular system

Zhuoquan Chen, Bing Wang, Ruiming Kong, Yuting Song, Dongqing Shang, Zeping Gao, Teng Ma

Author Affiliations +

Proceedings Volume 12770, Optics in Health Care and Biomedical Optics XIII; 127702Q (2023) https://doi.org/10.1117/12.2687443
Event: SPIE/COS Photonics Asia, 2023, Beijing, China

Conference Poster

Abstract

In-stent restenosis (ISR) and its associated inflammation remains a significant concern for long-term patient outcomes following stent implantation in percutaneous coronary intervention (PCI). The problem is intricately associated with endothelial injury, excessive endothelialization, hyperproliferation of smooth muscle cells, and the infiltration of inflammatory molecules. However, commonly employed imaging techniques encounter challenges in simultaneously acquiring both vascular structural information and functional data related to inflammation. Here, we presented a novel Tri modality intravascular imaging system capable of simultaneous optical coherence tomography (OCT), near-infrared fluorescence (NIRF), ultrasound (US) imaging, and fabricated the OCT-NIRF-US catheter which outer diameter is 0.75 mm, aiming to provide a more comprehensive diagnostic tool for ISR and its associated inflammation. Experiments were conducted on atherosclerotic rabbits implanted with a scaffold, divided into two groups (n=3 each group) for assessment on the first and twenty-eighth day, respectively. Primary results demonstrated that the integrated OCT-NIRF-US intravascular system enables complementary structural imaging and functional imaging of inflammation. The system presents the potential to offer a more accurate assessment, providing with valuable insights into the ISR processing and assisting in the development of more precise clinical strategies.

(2023) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Zhuoquan Chen, Bing Wang, Ruiming Kong, Yuting Song, Dongqing Shang, Zeping Gao, and Teng Ma "Full assessment of in-stent restenosis and associated inflammation based on the integrated OCT-NIRF-US intravascular system", Proc. SPIE 12770, Optics in Health Care and Biomedical Optics XIII, 127702Q (27 November 2023); https://doi.org/10.1117/12.2687443

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available