Challenge-led, values-based interdisciplinary infrastructure for optical probes, devices, and drugs

Ahsan R. Akram

doi:10.1117/12.3005135

12 March 2024 Challenge-led, values-based interdisciplinary infrastructure for optical probes, devices, and drugs

Ahsan R. Akram

Proceedings Volume 12822, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024; 1282207 (2024) https://doi.org/10.1117/12.3005135
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

The Translational Healthcare Technologies (THT) group has evolved over the last decade to develop a translational infrastructure that is challenge-led with people focused values and embedded patient engagement. The THT champions team science and is developing and translating into patient cohorts, cutting edge tools to delineate pathophysiology with a focus on pulmonary and ocular applications. This paper describes the infrastructure within Edinburgh BioQuarter and highlights some studies where we have developed chemical compounds to characterise lung pathologies such as pneumonia, acute respiratory distress syndrome (ARDS), pulmonary fibrosis and lung cancer. We describe the bench-to-bedside assessment of these compounds for gram-negative bacterial detection, neutrophil activation, matrix metalloproteinase (in fibrosis) detection and pre-clinical targets including fibroblast activation protein (cancer detection), T cell activity and bacterial detection. We also describe the development of two next generation fibre-based imaging technologies: a LED based tri-colour imaging system and a dual channel fluorescence lifetime imaging system. Using the THT infrastructure, these systems and chemical probes are now entering clinical trials in an academic institute.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Ahsan R. Akram "Challenge-led, values-based interdisciplinary infrastructure for optical probes, devices, and drugs", Proc. SPIE 12822, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024, 1282207 (12 March 2024); https://doi.org/10.1117/12.3005135

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KEYWORDS

Lung

Imaging systems

Cancer detection

Fluorescence lifetime imaging

Lung cancer

Optical imaging

Diagnostics

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