Long-term in vivo visualization of cortical blood perfusion after photothrombotic stroke with needle-shaped beam optical coherence tomography angiography

Xiangyu Guo; Jingjing Zhao; Adam de la Zerda; Liqun Sun

doi:10.1117/12.2692776

12 March 2024 Long-term in vivo visualization of cortical blood perfusion after photothrombotic stroke with needle-shaped beam optical coherence tomography angiography

Xiangyu Guo, Jingjing Zhao, Adam de la Zerda, Liqun Sun

Author Affiliations +

Proceedings Volume 12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII; 128300T (2024) https://doi.org/10.1117/12.2692776
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

High-resolution optical imaging is accompanied by a limited depth of field, making it challenging to obtain non-stitched, high-resolution images of samples with uneven surfaces without performing Z-axis scanning. To solve this problem, we introduced diffractive optical elements into the conventional OCT system and develop a needle-shaped beam OCT system with both long DOF and high resolution, which maintains 8μm lateral resolution over a depth range of 620μm. The system was then employed to perform a 10-day cortical blood perfusion observation after stroke, providing visual and mechanistic insight into stroke, deepening our understanding of the brain response after stroke.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Xiangyu Guo, Jingjing Zhao, Adam de la Zerda, and Liqun Sun "Long-term in vivo visualization of cortical blood perfusion after photothrombotic stroke with needle-shaped beam optical coherence tomography angiography", Proc. SPIE 12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII, 128300T (12 March 2024); https://doi.org/10.1117/12.2692776

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