OCT-based measurement of cerebral blood vessel structure, blood flow velocity, and blood transit time

Junxiong Zhou; Sida Liang; Jianbo Tang

doi:10.1117/12.3000870

12 March 2024 OCT-based measurement of cerebral blood vessel structure, blood flow velocity, and blood transit time

Junxiong Zhou, Sida Liang, Jianbo Tang

Proceedings Volume 12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII; 128300U (2024) https://doi.org/10.1117/12.3000870
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Accurate measurement of the microcirculation dynamics, including the blood vessel 3D structure, blood flow velocity and the blood flow transit time can not only improve our understanding of the pathology of microcirculation dysfunction-related disease, but also provide important parameters for disease diagnosis, prevention, and early treatment. In this work, we introduce a comprehensive optical coherence tomography (OCT)-based functional imaging technology for the 3D measurement of the micro vessel networks’ structure, blood flow velocity, and the blood flow transit time. The M-mode data acquisition (repeated A-scans) was employed in this technique. For blood vessel 3D structure imaging, we developed a first order field autocorrelation function (g1)-based adaptive analysis method to suppress the blood vessel tail artifacts and enhance the blood flow in small vessels. For blood flow velocity 3D imaging, we developed a set of quantitative dynamic analysis methods to measure both the axial and total blood flow velocity of the complex vessel network. We further developed a graphing method to obtain the 3D topological parameters of the 3D vessel network, including the vessel skeleton, branching, vessel diameter, and the blood flow speed at each location. With those information, we are able to, to the best of our knowledge, obtain the 3D blood transit time in the complex vessel network for the first of time. The proposed technique has the advantage of obtaining these three important blood flow biomarkers from a single data acquisition, which greatly simplifies the experiment procedure. The proposed OCT approach has a wide application in the field of microcirculation dysfunction-related disease studies.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Junxiong Zhou, Sida Liang, and Jianbo Tang "OCT-based measurement of cerebral blood vessel structure, blood flow velocity, and blood transit time", Proc. SPIE 12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII, 128300U (12 March 2024); https://doi.org/10.1117/12.3000870

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available