Michael J. Serafino,1 Clayton Walker,1,2 Patricia M. Quiñones,1 Juemei Wang,1 Frank D. Macías-Escrivá,1 John S. Oghalai,1 Brian E. Applegatehttps://orcid.org/0000-0003-2795-56781
1The Univ. of Southern California (United States) 2Texas A&M Univ. (United States)
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We report dynamic optical coherence tomography (D-OCT) images of the organ of Corti (ooC) in ex vivo mouse cochleas. The ooC is responsible for transducing sound-evoked mechanical vibrations and amplifying them in the process of hearing. Thorough knowledge of the micromechanical properties of the ooC is required for understanding how hearing functions. Recently, OCT has emerged as a safe and effective tool to probe the inner workings of the cochlea and ooC. However, OCT is limited in its ability to directly resolve cellular architecture due to limited optical scattering-based contrast between different cell types. D-OCT is a label-free method capable of probing sub-resolution movements by analyzing speckle and phase information from standard OCT data as a function of time. We show that key structures in the ooC can be identified with D-OCT versus standard OCT, and that D-OCT has the potential to characterize the ooC and advance our understanding of the process of hearing.
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(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.
Michael J. Serafino,Clayton Walker,Patricia M. Quiñones,Juemei Wang,Frank D. Macías-Escrivá,John S. Oghalai, andBrian E. Applegate
"Dynamic optical coherence tomography strongly enhances contrast in the ex vivo murine cochlea", Proc. SPIE 12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII, 128300X (12 March 2024); https://doi.org/10.1117/12.3005635
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Michael J. Serafino, Clayton Walker, Patricia M. Quiñones, Juemei Wang, Frank D. Macías-Escrivá, John S. Oghalai, Brian E. Applegate, "Dynamic optical coherence tomography strongly enhances contrast in the ex vivo murine cochlea," Proc. SPIE 12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII, 128300X (12 March 2024); https://doi.org/10.1117/12.3005635