Rapid rotary-scanning photoacoustic computed tomography for pharmacokinetic monitoring in small animals

Seongwook Choi; Jinge Yang; Chulhong Kim

doi:10.1117/12.3001183

12 March 2024 Rapid rotary-scanning photoacoustic computed tomography for pharmacokinetic monitoring in small animals

Seongwook Choi, Jinge Yang, Chulhong Kim

Proceedings Volume 12842, Photons Plus Ultrasound: Imaging and Sensing 2024; 128420B (2024) https://doi.org/10.1117/12.3001183
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Enhancing the monitoring of dynamic changes in organs is crucial for understanding biological processes and diseases. Current small-animal imaging techniques have limitations in contrast, sensitivity, and spatial/temporal resolution. We propose a rapid rotary-scanning photoacoustic computed tomography (PACT) approach that addresses these limitations. Using a rapid rotary-scanning technique with a hemispherical transducer array, we monitor dynamic change in mice. Leveraging the near-infrared spectral window, our method enables visualization of deep-seated structures across multiple planes in living mammalian organs. Our results demonstrate high image quality, rich spectroscopic contrast, and improved temporal resolution. PACT holds significant potential as a valuable tool for studying pharmacokinetics in preclinical research, offering insights into complex biological processes and facilitating the development of targeted therapeutics.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Seongwook Choi, Jinge Yang, and Chulhong Kim "Rapid rotary-scanning photoacoustic computed tomography for pharmacokinetic monitoring in small animals", Proc. SPIE 12842, Photons Plus Ultrasound: Imaging and Sensing 2024, 128420B (12 March 2024); https://doi.org/10.1117/12.3001183

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