Analysis and correction of backscattering polarimetric aberration induced by tissue surface geometry: a pilot ex-vivo study

Wei Jiao; Zheng Zhang; Honghui He; Hui Ma

doi:10.1117/12.3000813

12 March 2024 Analysis and correction of backscattering polarimetric aberration induced by tissue surface geometry: a pilot ex-vivo study

Wei Jiao, Zheng Zhang, Honghui He, Hui Ma

Author Affiliations +

Proceedings Volume 12845, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2024; 128450D (2024) https://doi.org/10.1117/12.3000813
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

Polarization imaging techniques have been extensively employed in biomedical studies and clinical applications. As a comprehensive polarization representation, the Mueller matrix (MM) can provide abundant polarization-related information of biomedical samples. For quantitative information acquisition, groups of polarization basic parameters (PBPs) have been obtained through MM analysis and demonstrated as effective structural characterization tools of tissue samples. Recently, MM polarimetric endoscopy has shown great clinical diagnostic potential. For in-vivo polarimetry such as gastrointestinal MM endoscopy of human internal organ cavities, the complicated undulating tissue surface geometry delivers an inescapable occurrence of oblique incidence, which induces a prominent aberration to backscattering tissue polarimetry. Thus, quantitatively analyzing and reducing the polarimetric aberration induced by oblique incidence are crucial for in-vivo precision MM endoscopy. In this study, we quantitatively analyze the polarimetric aberration induced by tissue surface geometry on PBPs. A correlation heatmap is obtained as applicable criteria to select appropriate incident angle for different PBPs. Based on the analyzing results, we propose two aberration correction strategies of parameter selection and azimuth rotation, which are suitable for tissue samples with randomly and well-aligned fiber textures, respectively. Both strategies are demonstrated to be effective in the ex-vivo human gastric muscularis tissue experiment. The findings presented in this study can be useful to provide accurate polarization imaging results, widely applied on in-vivo polarimetric endoscopy for tissues with complicated surface topography.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Wei Jiao, Zheng Zhang, Honghui He, and Hui Ma "Analysis and correction of backscattering polarimetric aberration induced by tissue surface geometry: a pilot ex-vivo study", Proc. SPIE 12845, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2024, 128450D (12 March 2024); https://doi.org/10.1117/12.3000813

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