Effects of blood type and number concentration on the circulation time of micro-sized erythrocyte-derived optical particles in mice

G. Swajian; S. Zaman; C.-H. Lee; E. Nguyen; C. Huynh; O. Lai; J. S. Nelson; B. Choi; W. Jia; B. Anvari

doi:10.1117/12.3003013

13 March 2024 Effects of blood type and number concentration on the circulation time of micro-sized erythrocyte-derived optical particles in mice

G. Swajian, S. Zaman, C.-H. Lee, E. Nguyen, C. Huynh, O. Lai, J. S. Nelson, B. Choi, W. Jia, B. Anvari

Author Affiliations +

Proceedings Volume 12859, Colloidal Nanoparticles for Biomedical Applications XIX; 1285908 (2024) https://doi.org/10.1117/12.3003013
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Erythrocyte-derived optical microparticles containing near infrared (NIR) dyes such as indocyanine green (ICG) present a promising platform for fluorescence imaging and laser treatment of abnormal vasculature, including port wine birthmarks. Herein, we have investigated the effects of blood type utilized in fabricating these microparticles, and the number density of the particles on their circulation time in mice by real-time NIR fluorescence imaging of the dermal vasculature. We find that the emission half-life of microparticles engineered from human O⁺ blood type increases by approximately two-fold as compared to those engineered from B⁺ blood type. Increasing the number density of the microparticles fabricated from O⁺ blood type from ~0.5 millions/μl to 1.6 millions/μl is associated with nearly a fourfold increase in the emission half-life of the particles. These findings emphasize the importance of blood type and number density in engineering erythrocyte-derived particles for clinical applications as treatment of PWBs.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

G. Swajian, S. Zaman, C.-H. Lee, E. Nguyen, C. Huynh, O. Lai, J. S. Nelson, B. Choi, W. Jia, and B. Anvari "Effects of blood type and number concentration on the circulation time of micro-sized erythrocyte-derived optical particles in mice", Proc. SPIE 12859, Colloidal Nanoparticles for Biomedical Applications XIX, 1285908 (13 March 2024); https://doi.org/10.1117/12.3003013

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available