CaMKIIδ editing through CRISPR-cas9 to treat heart disease

Kai Wang

doi:10.1117/12.3013151

8 January 2024 CaMKIIδ editing through CRISPR-cas9 to treat heart disease

Kai Wang

Proceedings Volume 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023); 129241V (2024) https://doi.org/10.1117/12.3013151
Event: 3rd International Conference on Biological Engineering and Medical Science (ICBioMed2023), 2023, ONLINE, United Kingdom

Abstract

CRISPR/Cas9 is an emerging technology developed in recent years. Because of its strength, specificity, and efficiency, the CRISPR-Cas gene editing method can swiftly and correctly screen the whole genome, which is convenient for gene therapy for particular illnesses. As a result, the technology has been greatly developed and applied in basic science and applied science such as gene editing. This study examined how CaMKIIδ genes could be modified using CRISPR-cas9 to remove oxidation-sensitive methionine residues and so reduce ischemia/reperfusion (IR) injury. Then the heart sections of mice before IR were used as control and whether the post-IR editing was performed or not was compared. It was found that the post-IR mice were protected from fibrosis after editing by CRISPR-cas9, which was the same as the control group. This successful case proves that CRISPR-cas9 technology has great effect on heart disease which is also an important way for us to overcome hereditary heart disease in the future.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Kai Wang "CaMKIIδ editing through CRISPR-cas9 to treat heart disease", Proc. SPIE 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023), 129241V (8 January 2024); https://doi.org/10.1117/12.3013151

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