Dual-modality bioluminescence and ultrasound 3D 360-degree imaging system for small animal tumor imaging using homemade transducers

Shih-Po Su; Huihua Kenny Chiang

doi:10.1117/12.3009797

1 April 2024 Dual-modality bioluminescence and ultrasound 3D 360-degree imaging system for small animal tumor imaging using homemade transducers

Shih-Po Su, Huihua Kenny Chiang

Author Affiliations +

Proceedings Volume 12932, Medical Imaging 2024: Ultrasonic Imaging and Tomography; 129320P (2024) https://doi.org/10.1117/12.3009797
Event: SPIE Medical Imaging, 2024, San Diego, California, United States

Abstract

The development of a dual-modality bioluminescence/ultrasound imaging system marks a significant advancement in preclinical research, particularly for creating accurate 3D tumor models. This system combines the long-term tumor tracking capabilities of bioluminescence imaging with the soft tissue examination strengths of ultrasound imaging. Its effectiveness in delineating tumor boundaries makes it an invaluable tool in oncology and related medical fields, enhancing our understanding of tissue structures and anomalies. The homemade 7.8MHz ultrasound transducers were used to obtain structural images of nude mice, while an EMCCD camera captured functional bioluminescence images. This combination allowed for the reconstruction of 3D bioluminescence emissions, effectively integrating 3D bioluminescence tomography with 3D ultrasound. This dual-modality approach resulted in highly accurate tumor localization and morphology details, as indicated by a high DICE coefficient of 88.5% and minimal localization error of 0.4mm. This demonstrates the system's capability in precise tumor mapping.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Shih-Po Su and Huihua Kenny Chiang "Dual-modality bioluminescence and ultrasound 3D 360-degree imaging system for small animal tumor imaging using homemade transducers", Proc. SPIE 12932, Medical Imaging 2024: Ultrasonic Imaging and Tomography, 129320P (1 April 2024); https://doi.org/10.1117/12.3009797

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