Innovative pyroelectric biosensor for detecting picogram level of neurodegeneration protein biomarkers

Concetta Di Natale; Sara Coppola; Veronica Vespini; Volodymyr Tkachenko; Simone Russo; Giuseppina Luciani; Giuseppe Vitiello; Daniele Tammaro; Pietro Ferraro; Francesca Ferranti; Silvia Mari; Sara La Manna; Daniela Marasco; Pier Luca Maffettone; Simonetta Grilli

doi:10.1117/12.3022448

20 June 2024 Innovative pyroelectric biosensor for detecting picogram level of neurodegeneration protein biomarkers

Concetta Di Natale, Sara Coppola, Veronica Vespini, Volodymyr Tkachenko, Simone Russo, Giuseppina Luciani, Giuseppe Vitiello, Daniele Tammaro, Pietro Ferraro, Francesca Ferranti, Silvia Mari, Sara La Manna, Daniela Marasco, Pier Luca Maffettone, Simonetta Grilli

Author Affiliations +

Proceedings Volume 13008, Biophotonics in Point-of-Care III; 130080C (2024) https://doi.org/10.1117/12.3022448
Event: SPIE Photonics Europe, 2024, Strasbourg, France

Abstract

Human perpetual exposure to several pollutants such as smoke, radiation, and toxic chemical substances, causes an excessive production of reactive oxygen species (ROS), that leads to the onset of neurodegeneration diseases. This knowledge has highlighted the importance of frequent monitoring people health with innovative biosensors able to detect pathological conditions at the initial stage. Indeed, it is mainly stated that neurodegenerative diseases can be effectively treated only if diagnosed very early. In this context, the structural aggregation of biomolecules in different districts of the brain, seem to play a key role in the neurodegeneration development mechanism becoming eligible targets for an early diagnosis. Hereby, we propose an innovative technique for detecting such biomolecules, e.g. Tau, by exploiting a pyro-electrohydrodynamic effect that is able to generate and accumulate tiny droplets of analyte on the surface of a reactive glass slide. We call the technique p-jet and we tested it in case of serial dilutions of Tau protein to demonstrate the consistency of the procedure under an immunodetection-based protocol.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

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Concetta Di Natale, Sara Coppola, Veronica Vespini, Volodymyr Tkachenko, Simone Russo, Giuseppina Luciani, Giuseppe Vitiello, Daniele Tammaro, Pietro Ferraro, Francesca Ferranti, Silvia Mari, Sara La Manna, Daniela Marasco, Pier Luca Maffettone, and Simonetta Grilli "Innovative pyroelectric biosensor for detecting picogram level of neurodegeneration protein biomarkers", Proc. SPIE 13008, Biophotonics in Point-of-Care III, 130080C (20 June 2024); https://doi.org/10.1117/12.3022448

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