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20 November 2024 Evaluation of superconducting strip single photon detector-based system for singlet oxygen luminescence detection
Shengdong Cui, Sen Wang, Xingran Guo, Xianzeng Zhang, Timothy C. Zhu, Zheng Huang
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Proceedings Volume 13242, Optics in Health Care and Biomedical Optics XIV; 1324209 (2024) https://doi.org/10.1117/12.3036261
Event: SPIE/COS Photonics Asia, 2024, Nantong, Jiangsu, China
Abstract
Background: Singlet oxygen (1O2) is a key therapeutic molecule in photodynamic therapy (PDT). Quantitation of 1O2 luminescence is important for monitoring and optimizing PDT process. Objective: The aim of this study was to evaluate a custom-built superconducting strip single photon detector (SSPD)-based time-resolved photon counting system for 1O2 luminescence detection. Materials and Methods: The wavelength responses of optical collection system were verified by a spectrum analyzer. A dual-channel signal generator simulates pulsed signals of different frequencies were used to verify the circuit system. 1O2 luminescence generated by the photoexcitation of Rose Bengal solution was examined. Results: The 1O2 detection system could transmit photons of 1270 nm and the time-resolved system showed the response down to the nanosecond range and was capable of converting the different time responses into a square wave signal. When 10 μM aqueous and methanolic RB solutions were excited with a 20 mW 532 nm laser the measured 1O2 lifetimes were 2.93±0.37 μs and 9.45±0.83 μs, respectively. At the same concentration, when the excitation power increased the number of singlet oxygen produced per unit of time also increased. Conclusions: The custom-built SSPD-based 1O2 detection system provides a reliable and sensitive means for the quantitation of 1O2 luminescence generated from PDT process.
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Shengdong Cui, Sen Wang, Xingran Guo, Xianzeng Zhang, Timothy C. Zhu, and Zheng Huang "Evaluation of superconducting strip single photon detector-based system for singlet oxygen luminescence detection", Proc. SPIE 13242, Optics in Health Care and Biomedical Optics XIV, 1324209 (20 November 2024); https://doi.org/10.1117/12.3036261
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KEYWORDS
Luminescence
Oxygen
Single photon detectors
Photodynamic therapy
Superconductors
Photon counting
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