Synthesis and photodynamic evaluation of SZ-SiPc-I2 in BxPC-3 human pancreatic cancer cells

Jincheng Li; Tiantian Zhang; Jianling Chen; Yiru Peng

doi:10.1117/12.3058117

10 January 2025 Synthesis and photodynamic evaluation of SZ-SiPc-I2 in BxPC-3 human pancreatic cancer cells

Jincheng Li, Tiantian Zhang, Jianling Chen, Yiru Peng

Author Affiliations +

Proceedings Volume 13507, Seventeenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2024); 135070X (2025) https://doi.org/10.1117/12.3058117
Event: Seventeenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2024), 2024, Shaya, China

Abstract

Silicon phthalocyanine complexes, characterized by two additional axial coordination sites, have gained significant attention as second-generation photosensitizers for Photodynamic Therapy (PDT). In this study, di-(5-methylthiazole-1- ethoxy) axially substituted phthalocyanine (SZ-SiPc) was synthesized and further modified through methyl iodide treatment to produce di-(4-N-methyl-5-methylthiazole-1-ethoxy) axially substituted phthalocyanine diiodide (SZ-SiPc-I2). The cellular uptake, phototoxicity, and dark toxicity of SZ-SiPc-I2 were evaluated in BxPC-3 human pancreatic cancer cells using laser scanning confocal microscopy and cytotoxicity assays. Results revealed that SZ-SiPc-I2 was rapidly and effectively internalized by BxPC-3 cells, exhibited excellent biocompatibility, and demonstrated high phototoxicity under light irradiation. These findings suggest that SZ-SiPc-I2 holds great promise as a novel and effective photosensitizer for PDT, offering potential advancements in cancer therapy.

(2025) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Jincheng Li, Tiantian Zhang, Jianling Chen, and Yiru Peng "Synthesis and photodynamic evaluation of SZ-SiPc-I2 in BxPC-3 human pancreatic cancer cells", Proc. SPIE 13507, Seventeenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2024), 135070X (10 January 2025); https://doi.org/10.1117/12.3058117

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