Fluorescence spectroscopy of normal and atheromatous human aorta: optimum illumination wavelength

Andrew L. Alexander; Carolyn M.C. Davenport; Arthur F. Gmitro

doi:10.1117/12.44012

1 May 1991 Fluorescence spectroscopy of normal and atheromatous human aorta: optimum illumination wavelength

Andrew L. Alexander, Carolyn M.C. Davenport, Arthur F. Gmitro

Proceedings Volume 1425, Diagnostic and Therapeutic Cardiovascular Interventions; (1991) https://doi.org/10.1117/12.44012
Event: Optics, Electro-Optics, and Laser Applications in Science and Engineering, 1991, Los Angeles, CA, United States

Abstract

The purpose of this investigation was to determine which illumination wavelength produces the largest differences between the fluorescence emission spectra of normal and atheromatous vascular tissue. The fluorescence spectra for 12 excitation wavelengths ranging between 270 nm and 470 nm were examined and compared. The Hotelling trace, a figure of merit describing class separability, was used to compare the excitation wavelengths. Preliminary results indicate that illumination in the range from 314 nm to 334 nm consistently performed well. Wavelengths in the 364 nm to 436 nm range also showed promising performance for a limited data set. These results were found to be relatively independent of the catheter angel and distance to the tissue.

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Andrew L. Alexander, Carolyn M.C. Davenport, and Arthur F. Gmitro "Fluorescence spectroscopy of normal and atheromatous human aorta: optimum illumination wavelength", Proc. SPIE 1425, Diagnostic and Therapeutic Cardiovascular Interventions, (1 May 1991); https://doi.org/10.1117/12.44012

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KEYWORDS

Luminescence

Tissues

Diagnostics and therapeutics

Fluorescence spectroscopy

Tissue optics

Monochromators

Optical fibers

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