Photodynamic therapy in the prophylactic management of bladder cancer

Unyime O. Nseyo M.D.; Scott L. Lundahl; Daniel C. Merrill M.D.

doi:10.1117/12.44068

1 June 1991 Photodynamic therapy in the prophylactic management of bladder cancer

Unyime O. Nseyo M.D., Scott L. Lundahl, Daniel C. Merrill M.D.

Proceedings Volume 1426, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques; (1991) https://doi.org/10.1117/12.44068
Event: Optics, Electro-Optics, and Laser Applications in Science and Engineering, 1991, Los Angeles, CA, United States

Abstract

Nine patients were treated with red light whole bladder photodynamic therapy (WBPDT): five had mucosal involvement (Ta) and four submucosal invasion (T1). Patients received slow intravenous injection with 2mg/kg body weight of photofrin 48-72 hours before undergoing global light treatment via a 22-French cystoscope with a 400-micron quartz fiber bulb (isotropic) tip fiber. Three months after PDT, eight of the patients had normal cystoscopy, and negative biopsy and urine cytology. Two patients who had recurrences at six and twelve months were retreated with a higher dose (20 J/cm2). They had no increased morbidity and no evidence of recurrent disease six months later. WBPDT should be considered as an important alternative treatment for patients who have recurrent or refractory superficial bladder cancer.

Citation Download Citation

Unyime O. Nseyo M.D., Scott L. Lundahl, and Daniel C. Merrill M.D. "Photodynamic therapy in the prophylactic management of bladder cancer", Proc. SPIE 1426, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques, (1 June 1991); https://doi.org/10.1117/12.44068

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