Experimental study on the killing effect of 510.6-nm green copper-vapor laser HPD on transplanted tumors in animals

Qizhong Zhang; Xusheng Mu; Boling Cai; Xiangda Lin; Feng Li; Jun Lin; Xiuhong Wu; Lin Lu; Moqin Song

doi:10.1117/12.137034

5 March 1993 Experimental study on the killing effect of 510.6-nm green copper-vapor laser HPD on transplanted tumors in animals

Qizhong Zhang, Xusheng Mu, Boling Cai, Xiangda Lin, Feng Li, Jun Lin, Xiuhong Wu, Lin Lu, Moqin Song

Author Affiliations +

Proceedings Volume 1616, International Conference on Photodynamic Therapy and Laser Medicine; (1993) https://doi.org/10.1117/12.137034
Event: International Conference on Photodynamic Therapy and Laser Medicine, 1991, Beijing, China

Abstract

Intraperitoneal injection of hematoporphyrin derivative (50 mg/kg) was given to mice with S180 and M16-MB. Seventy-two hours after injection, the tumor was radiated by 510.6 nm wavelength copper vapor laser. Power density was 330 - 660 mw/cm². Energy density was 200 - 270 J/cm². After the irradiation, the volume and weight of the tumors were decreased significantly compared with that of the other four groups. Necrosis was seen in the center of the irradiated tumor by pathological examination. The depth of necrosis ranged from 5.5 - 8.8 mm with an average of about 7 mm. Swollen mitochondria, dilated rough endoplasmic reticulum, and broken plasma membrane could be seen in cancer cells by electrical microscope. Experimental results showed that copper vapor laser could be used as the light source of photodynamic therapy (PDT) for the treatment of superficial cancer. The killing effect and cause of cancer recurrence in PDT treatment of cancer is discussed.

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Qizhong Zhang, Xusheng Mu, Boling Cai, Xiangda Lin, Feng Li, Jun Lin, Xiuhong Wu, Lin Lu, and Moqin Song "Experimental study on the killing effect of 510.6-nm green copper-vapor laser HPD on transplanted tumors in animals", Proc. SPIE 1616, International Conference on Photodynamic Therapy and Laser Medicine, (5 March 1993); https://doi.org/10.1117/12.137034

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