Near-IR Fourier transform Raman spectroscopy in surgery and medicine: ophthalmic applications

Shuming Nie; Nai-Teng Yu; Qiushi Ren

doi:10.1117/12.137431

14 August 1992 Near-IR Fourier transform Raman spectroscopy in surgery and medicine: ophthalmic applications

Shuming Nie, Nai-Teng Yu, Qiushi Ren

Proceedings Volume 1644, Ophthalmic Technologies II; (1992) https://doi.org/10.1117/12.137431
Event: OE/LASE '92, 1992, Los Angeles, CA, United States

Abstract

This report describes the application of a recently developed spectroscopic technique, near- infrared-excited Fourier transform Raman scattering (abbreviated as near-IR FT-Raman) in the molecular-level characterization of normal and pathological human ocular tissues. The near-IR FT-Raman technique was shown to be particularly well-suited for the noninvasive analysis of intact ophthalmic samples because it exhibits such attractive features as complete fluorescence elimination, great sampling flexibility, high data acquisition speed, and measurement accuracy. For both intact human lenses and corneas, systematic FT-Raman studies were carried out in order to probe detailed molecular changes involved in cataract formation and cornea diseases. FT-Raman measurement was also made for synthetic biomaterials that can be attached to the corneal surface for laser refractive surgery. The technique of near-IR FT- Raman spectroscopy is potentially a nondestructive, non-invasive fingerprinting modality for monitoring lens aging, cataract formation, and corneal disease development.

Citation Download Citation

Shuming Nie, Nai-Teng Yu, and Qiushi Ren "Near-IR Fourier transform Raman spectroscopy in surgery and medicine: ophthalmic applications", Proc. SPIE 1644, Ophthalmic Technologies II, (14 August 1992); https://doi.org/10.1117/12.137431

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available