Simple optical theory for light dosimetry during PDT (Invited Paper)

Steven L. Jacques

doi:10.1117/12.60938

1 June 1992 Simple optical theory for light dosimetry during PDT (Invited Paper)

Steven L. Jacques

Proceedings Volume 1645, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy; (1992) https://doi.org/10.1117/12.60938
Event: OE/LASE '92, 1992, Los Angeles, CA, United States

Abstract

Photons are one of the three major reactants in the photodynamic reaction that yields toxic photoproduct for cell killing. Dosimetry of light is a major concern when planning a photodynamic therapy (PDT) protocol. This paper presents a very simple approach toward the tissue optics with a practical conclusion about how tissue optics affects planning of day-to-day PDT dosimetry. The paper does not address all the complexities of real tissue dosimetry, such as heterogeneous tissues, variable absorption due to changing tissue blood content, and variable tissue oxygen levels. The paper outlines the optical behavior in a homogeneous tissue, which is a starting point for understanding light dosimetry.

Citation Download Citation

Steven L. Jacques "Simple optical theory for light dosimetry during PDT (Invited Paper)", Proc. SPIE 1645, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy, (1 June 1992); https://doi.org/10.1117/12.60938

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