Autologous bone marrow transplantation by photodynamic therapy

Kirpal S. Gulliya

doi:10.1117/12.137505

1 June 1992 Autologous bone marrow transplantation by photodynamic therapy

Kirpal S. Gulliya

Proceedings Volume 1650, Medical Lasers and Systems; (1992) https://doi.org/10.1117/12.137505
Event: OE/LASE '92, 1992, Los Angeles, CA, United States

Abstract

Simultaneous exposure of Merocyanine 540 dye containing cultured tumor cells to 514-nm laser light (93.6 J/cm²) results in virtually complete cell destruction. Under identical conditions, 40% of the normal progenitor (CFU-GM) cells survive the treatment. Laser- photoradiation treated, cultured breast cancer cells also were killed, and living tumor cells could not be detected by clonogenic assays or by anti-cytokeratin monoclonal antibody method. Thus, laser photoradiation therapy could be useful for purging of contaminating tumor cells from autologous bone marrow.

Citation Download Citation

Kirpal S. Gulliya "Autologous bone marrow transplantation by photodynamic therapy", Proc. SPIE 1650, Medical Lasers and Systems, (1 June 1992); https://doi.org/10.1117/12.137505

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