Nonlinear spectroscopy of chiral molecules: new spectroscopic techniques for studying left-right mirror asymmetry of biological molecules

A. V. Dubrovskii; Nikolai I. Koroteev; Aleksandr P. Shkurinov

doi:10.1117/12.146177

17 June 1993 Nonlinear spectroscopy of chiral molecules: new spectroscopic techniques for studying left-right mirror asymmetry of biological molecules

A. V. Dubrovskii, Nikolai I. Koroteev, Aleksandr P. Shkurinov

Author Affiliations +

Proceedings Volume 1922, Laser Study of Macroscopic Biosystems; (1993) https://doi.org/10.1117/12.146177
Event: Laser Spectroscopy of Biomolecules: 4th International Conference on Laser Applications in Life Sciences, 1992, Jyvaskyla, Finland

Abstract

Molecular left-right asymmetry is an origin of nonvanishing even order optical nonlinear susceptibilities of non-racemic solutions of chiral molecules. New non-linear optical spectroscopic schemes based on three- and five-wave interactions in chiral homogeneous isotropic media (symmetry forbidden in centrosymmetric racemic solutions) are investigated with the aim to develop a novel technique to clearly distinguish between left and right mirror isomers of biological molecules and to measure their individual nonlinear optical hyperpolarizabilities, and vibrational spectra. Through second harmonic generation (SHG) due to quadratic dipolar nonlinearity is still symmetry forbidden in optically active liquids yet we have succeeded in experimental observation, for the first time, of noncollinear SHG due to five-mixing process according to a scheme 2(omega) equals 3(omega) - (omega) , governed by a fourth order susceptibility tensor (chi) ⁽⁴D). SHG signal is found to be well collimated and quasi phase-matched, it shows theoretically predicted polarization, spectral and temporal properties.

Citation Download Citation

A. V. Dubrovskii, Nikolai I. Koroteev, and Aleksandr P. Shkurinov "Nonlinear spectroscopy of chiral molecules: new spectroscopic techniques for studying left-right mirror asymmetry of biological molecules", Proc. SPIE 1922, Laser Study of Macroscopic Biosystems, (17 June 1993); https://doi.org/10.1117/12.146177

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available