Functional monitoring of tissues using frequency-domain laser light scattering

Yurii P. Sinichkin; Alexander G. Bogoroditsky; Albert H. Mavlyutov; Gennady A. Smolyakov; Valery V. Tuchin; Ilya V. Yaroslavsky

doi:10.1117/12.167458

1 February 1994 Functional monitoring of tissues using frequency-domain laser light scattering

Yurii P. Sinichkin, Alexander G. Bogoroditsky, Albert H. Mavlyutov, Gennady A. Smolyakov, Valery V. Tuchin, Ilya V. Yaroslavsky

Author Affiliations +

Proceedings Volume 2082, Quantification and Localization Using Diffuse Photons in a Highly Scattering Medium; (1994) https://doi.org/10.1117/12.167458
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

Determination of the optical parameters of tissues is a necessary element of laser medical diagnostics and therapy planning. In this work a mathematical model of the photon migration in tissues is considered in the assumption of the harmonic modulation of the incident laser light. The scattering coefficient and the photon's life time in virtually absorbed state can be calculated from the modulation coefficient and phase shift between incident and scattered light. Frequency-domain measurements were performed using two laser diodes (wavelengths 805 and 850 nm) as light-modulated sources and fiber-optic light guides for delivering the light to tissues surface and collecting the back scattering output. It is shown that measured difference in phase shift of scattered light intensity is proportional to difference in mean pathlength of photons at two wavelengths.

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Yurii P. Sinichkin, Alexander G. Bogoroditsky, Albert H. Mavlyutov, Gennady A. Smolyakov, Valery V. Tuchin, and Ilya V. Yaroslavsky "Functional monitoring of tissues using frequency-domain laser light scattering", Proc. SPIE 2082, Quantification and Localization Using Diffuse Photons in a Highly Scattering Medium, (1 February 1994); https://doi.org/10.1117/12.167458

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KEYWORDS

Tissues

Modulation

Light scattering

Laser scattering

Tissue optics

Phase shifts

Scattering

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