Fourier transform infrared studies on conformational changes of calmodulin induced by metal-ion binding

Masayuki Nara; Masaru Tanokura; Mitsuo Tasumi

doi:10.1117/12.166602

31 January 1994 Fourier transform infrared studies on conformational changes of calmodulin induced by metal-ion binding

Masayuki Nara, Masaru Tanokura, Mitsuo Tasumi

Proceedings Volume 2089, 9th International Conference on Fourier Transform Spectroscopy; (1994) https://doi.org/10.1117/12.166602
Event: Fourier Transform Spectroscopy: Ninth International Conference, 1993, Calgary, Canada

Abstract

Fourier transform infrared (FT-IR) spectroscopy has been used to examine conformational changes of calmodulin (CaM) by metal-ion binding. It has been found that the amide-I mode and the COO^- stretching modes are markers for investigating the effects of metal- ion binding on CaM. These modes indicate that the effect of Mg²⁺ on CaM is different from that of Ca²⁺, and that the effects of Sr²⁺ and Cd²⁺ on CaM are similar to but not identical with that of Ca²⁺. This result suggests that the metal -COO^- interaction is one of the important factors regulating the 3-D structure of CaM.

Citation Download Citation

Masayuki Nara, Masaru Tanokura, and Mitsuo Tasumi "Fourier transform infrared studies on conformational changes of calmodulin induced by metal-ion binding", Proc. SPIE 2089, 9th International Conference on Fourier Transform Spectroscopy, (31 January 1994); https://doi.org/10.1117/12.166602

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