Dynamics of the binding and change of photosensitizers of phthalocyanine row concentration in malignant tumors: experimental results

Victor B. Loschenov; Anna I. Volkova; A. I. Volegov; T. A. Kramarenko; Sergey S. Kharnas; Anna M. Posypanova; Alexander A. Stratonnikov; Eugeny A. Lukyanets; P. V. Poleshkin; Nadezgda L. Torshina

doi:10.1117/12.179014

28 June 1994 Dynamics of the binding and change of photosensitizers of phthalocyanine row concentration in malignant tumors: experimental results

Victor B. Loschenov, Anna I. Volkova, A. I. Volegov, T. A. Kramarenko, Sergey S. Kharnas, Anna M. Posypanova, Alexander A. Stratonnikov, Eugeny A. Lukyanets, P. V. Poleshkin, Nadezgda L. Torshina

Author Affiliations +

Proceedings Volume 2100, Cell and Biotissue Optics: Applications in Laser Diagnostics and Therapy; (1994) https://doi.org/10.1117/12.179014
Event: Volga Laser Tour '93, 1993, Moscow, Russian Federation

Abstract

The results of investigations of photosensitizers distribution, accumulation and outputting in the process of photodynamic therapy on the model of Erlikh carcinoma in the experiment are adduced. Phthalocyanines of Al, differing in technology of synthesis and content of sulfa groups, have been used. The character of photosensitizer binding has been determined by the change of its spectral characteristics after binding with albumin in vitro and by analysis of fine structure of fluorescence spectra in vivo.

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Victor B. Loschenov, Anna I. Volkova, A. I. Volegov, T. A. Kramarenko, Sergey S. Kharnas, Anna M. Posypanova, Alexander A. Stratonnikov, Eugeny A. Lukyanets, P. V. Poleshkin, and Nadezgda L. Torshina "Dynamics of the binding and change of photosensitizers of phthalocyanine row concentration in malignant tumors: experimental results", Proc. SPIE 2100, Cell and Biotissue Optics: Applications in Laser Diagnostics and Therapy, (28 June 1994); https://doi.org/10.1117/12.179014

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