Determination of blood oxygenation in the brain by time-resolved reflectance spectroscopy: influence of the skin, skull, and meninges

Hanli Liu; Andreas H. Hielscher; Bertrand Beauvoit; Lihong V. Wang; Steven L. Jacques; Frank K. Tittel; Britton Chance

doi:10.1117/12.180783

21 July 1994 Determination of the blood oxygenation in the brain by time-resolved reflectance spectroscopy: contribution of vascular absorption and tissue background absorption

Hanli Liu, Andreas H. Hielscher, Bertrand Beauvoit, Lihong V. Wang, Steven L. Jacques, Frank K. Tittel, Britton Chance

Author Affiliations +

Proceedings Volume 2136, Biochemical Diagnostic Instrumentation; (1994) https://doi.org/10.1117/12.180783
Event: OE/LASE '94, 1994, Los Angeles, CA, United States

Abstract

The possibility of measuring the blood oxygenation in the brain with near infrared light has been studied. The goal of this study was to quantify the influence of different brain layers on brain blood oxygenation measurements. Experimental results obtained from time resolved reflectance measurements on layered tissue phantoms were compared to Monte Carlo simulations of layered models, diffusion theory, and in vivo measurements on the human head. Both the experimental results and simulations show that the absorption coefficient (mu) _a, which is closely related to the blood oxygenation, of deeper layers can be accessed in the time domain. Thus fitting analytical expressions found from diffusion theory only to the late part of the time resolved reflectance allows us to determine (mu) _a and subsequently the blood oxygenation of the deepest medium (e.g. brain tissue).

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Hanli Liu, Andreas H. Hielscher, Bertrand Beauvoit, Lihong V. Wang, Steven L. Jacques, Frank K. Tittel, and Britton Chance "Determination of the blood oxygenation in the brain by time-resolved reflectance spectroscopy: contribution of vascular absorption and tissue background absorption", Proc. SPIE 2136, Biochemical Diagnostic Instrumentation, (21 July 1994); https://doi.org/10.1117/12.180783

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