Integrating sphere measurements of tissue optical properties for accurate photodynamic therapy (PDT) dosimetry

Annika M.K. Nilsson; Roger Berg; Stefan Andersson-Engels

doi:10.1117/12.199183

18 January 1995 Integrating sphere measurements of tissue optical properties for accurate photodynamic therapy (PDT) dosimetry

Annika M.K. Nilsson, Roger Berg, Stefan Andersson-Engels

Author Affiliations +

Proceedings Volume 2323, Laser Interaction with Hard and Soft Tissue II; (1995) https://doi.org/10.1117/12.199183
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

A set-up with an integrating sphere and a narrow-beam arrangement was used in order to derive the optical properties in vitro of 1 mm thick tissue slabs. The measured macroscopic quantities, the reflectance, and the total transmittance were correlated to the tissue optical properties by Monte Carlo simulations. Mie calculations were performed to be able to calibrate the set-up with a solution of latex spheres and ink. Finally, the optical properties of rat liver samples were measured, before and after photodynamic therapy, showing approximately a 40% increase of the absorption coefficient at 650 nm due to the treatment.

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Annika M.K. Nilsson, Roger Berg, and Stefan Andersson-Engels "Integrating sphere measurements of tissue optical properties for accurate photodynamic therapy (PDT) dosimetry", Proc. SPIE 2323, Laser Interaction with Hard and Soft Tissue II, (18 January 1995); https://doi.org/10.1117/12.199183

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