Chlorin-type photosensitizers derived from vinyl porphyrins

Daniel Brault; B. Aveline; O. Delgado; Christine Vever-Bizet

doi:10.1117/12.199160

12 January 1995 Chlorin-type photosensitizers derived from vinyl porphyrins

Daniel Brault, B. Aveline, O. Delgado, Christine Vever-Bizet

Proceedings Volume 2325, Photodynamic Therapy of Cancer II; (1995) https://doi.org/10.1117/12.199160
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

The reaction of singlet oxygen with vinyl porphyrins, which was first described in the case of protoporphyrin, is reinvestigated as a route to chlorin type molecules. Various dicarboxylic chlorins were thus prepared and characterized for their chemical and photosensitizing properties. All of them efficiently photosensitize the production of singlet oxygen. Some of these compounds might be formed during photodynamic therapy with hematoporphyrin derivative or Photofrin. Their biological relevance is discussed.

Citation Download Citation

Daniel Brault, B. Aveline, O. Delgado, and Christine Vever-Bizet "Chlorin-type photosensitizers derived from vinyl porphyrins", Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); https://doi.org/10.1117/12.199160

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