In vivo and in vitro absorption spectrum of disulphonated aluminum phthalocyanine in tumor-bearing mice

Rinaldo Cubeddu; Gianfranco L. Canti; Antonio Pifferi; Paola Taroni; Gianluca Valentini

doi:10.1117/12.203445

1 March 1995 In vivo and in vitro absorption spectrum of disulphonated aluminum phthalocyanine in tumor-bearing mice

Rinaldo Cubeddu, Gianfranco L. Canti, Antonio Pifferi, Paola Taroni, Gianluca Valentini

Proceedings Volume 2371, 5th International Photodynamic Association Biennial Meeting; (1995) https://doi.org/10.1117/12.203445
Event: Fifth International Photodynamic Association Biennial Meeting, 1994, Amelia Island, FL, United States

Abstract

The absorption spectrum of disulphonated aluminum phthalocyanine (AlS₂Pc) between 650 nm and 695 nm was measured in vivo by means of time-resolved reflectance. The experiments were performed on mice bearing the L1210 leukemia 1, 4, and 7 hr after the i.p. administration of 2.5 mg/kg body weight (b.w.) of AlS₂Pc. The absorption peak is centered at 685 nm, red-shifted of 10 - 15 nm with respect to the spectra obtained in solution in various environments. Measurements performed in vitro confirm the results in vivo and seem to suggest that the extracellular environment can cause the shift in the absorption line shape.

Citation Download Citation

Rinaldo Cubeddu, Gianfranco L. Canti, Antonio Pifferi, Paola Taroni, and Gianluca Valentini "In vivo and in vitro absorption spectrum of disulphonated aluminum phthalocyanine in tumor-bearing mice", Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); https://doi.org/10.1117/12.203445

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