Photodynamic therapy of malignant mesothelioma of pleura

Trond Warloe; Helen Heyerdahl; Qian Peng; J. Hoie; E. Normann; O. Solheim; Johan Moan; Karl-Erik Giercksky

doi:10.1117/12.203444

1 March 1995 Photodynamic therapy of malignant mesothelioma of pleura

Trond Warloe, Helen Heyerdahl, Qian Peng, J. Hoie, E. Normann, O. Solheim, Johan Moan, Karl-Erik Giercksky

Proceedings Volume 2371, 5th International Photodynamic Association Biennial Meeting; (1995) https://doi.org/10.1117/12.203444
Event: Fifth International Photodynamic Association Biennial Meeting, 1994, Amelia Island, FL, United States

Abstract

Nine patients with malignant pleural mesothelioma underwent extensive surgery followed by intra-operative photodynamic therapy. Two mg/kg Photofrin was given 48 hours prior to surgery. The thoracic cavity and eventual remaining lung were exposed to 15 - 30 Joules/cm² of 630 nm laser light. Tumor tissue was analyzed by microscopic photometrical techniques. Five patients with mixed or epithelioid tumors with fluorescence intensity > 100 gray level/pixel seemed to benefit from the given therapy. One patient was free of disease 18 months after treatment. Two patients were treated for metastasis after 12 months with no sign of intrathoracic recurrence. Both are still alive, one without further sign of disease 32 months after initial treatment. Two patients presented generalized disease after 9 and 13 months and intrathoracic recurrence several months later. Two patients with poorly differentiated tumors and 2 patients with moderate to highly differentiated tumors, but with fluorescence intensity < 100 gray level/pixel, presented recurrences after 4 months. PDT-efficiency seems to be predicted by the intensity and distribution of drug-induced fluorescence in tumor tissue. PDT may enhance the possibility to achieve complete local tumor control after excision. Multimodal therapeutic approach of local and systemic disease seems mandatory to further improve survival.

Citation Download Citation

Trond Warloe, Helen Heyerdahl, Qian Peng, J. Hoie, E. Normann, O. Solheim, Johan Moan, and Karl-Erik Giercksky "Photodynamic therapy of malignant mesothelioma of pleura", Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); https://doi.org/10.1117/12.203444

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