Laser-induced stress transients: applications for molecular delivery

Thomas J. Flotte M.D.; Shun Lee; Hong Zhang; Daniel J. McAuliffe; Tina Douki; Apostolos George Doukas

doi:10.1117/12.209883

22 May 1995 Laser-induced stress transients: applications for molecular delivery

Thomas J. Flotte M.D., Shun Lee, Hong Zhang, Daniel J. McAuliffe, Tina Douki, Apostolos George Doukas

Proceedings Volume 2391, Laser-Tissue Interaction VI; (1995) https://doi.org/10.1117/12.209883
Event: Photonics West '95, 1995, San Jose, CA, United States

Abstract

Lasers can be used to enhance the delivery of a number of molecules. Other investigators have demonstrated local release of molecules from liposomes following laser irradiation, microbeam disruption of the cell membrane to increase cell transport, microbeam ablation of the zona pellucida surrounding the ovum to increase the chances of fertilization, and increased transcutaneous transport following ablation of the stratum corneum. Our experiments have shown that laser-induced stress transients can be utilized as a vector for intracellular delivery of molecules that may or may not normally cross the cell membrane. These two conditions have been tested with Photofrin and DNA. This technology may have applications in cell and molecular biology, cancer therapy, gene therapy, and others.

Citation Download Citation

Thomas J. Flotte M.D., Shun Lee, Hong Zhang, Daniel J. McAuliffe, Tina Douki, and Apostolos George Doukas "Laser-induced stress transients: applications for molecular delivery", Proc. SPIE 2391, Laser-Tissue Interaction VI, (22 May 1995); https://doi.org/10.1117/12.209883

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