Skin photosensitivity as a model in photodynamic therapy

Anna M. Richter; Ashok K. Jain; Alice J. Canaan; Howard Meadows; Julia G. Levy

doi:10.1117/12.230986

31 January 1996 Skin photosensitivity as a model in photodynamic therapy

Anna M. Richter, Ashok K. Jain, Alice J. Canaan, Howard Meadows, Julia G. Levy

Proceedings Volume 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities; (1996) https://doi.org/10.1117/12.230986
Event: BiOS Europe '95, 1995, Barcelona, Spain

Abstract

Skin photosensitivity is the most common side effect of photodynamic therapy (PDT) and in clinical situations needs to be avoided or at least minimized. However, because of the accessibility of skin tissue, skin photosensitivity represents a useful test system in vivo for evaluation of the pharmacokinetics of photosensitizers and light sources. Pig skin resembles in many aspects human skin and, therefore, is most suitable for these tests. Using pig skin photosensitivity as an end point, we evaluate the effect of cell loading with a photosensitizer, benzoporphyrin derivative (BPD verteporfin) following its intravenous administration either as a rapid bolus or slow infusion. Skin response to light activation indicated a very similar cell content of BPD. These results were in agrement with those obtained in an in vitro model. In addition, in the same pig skin photosensitivity model we compared the efficiency of activation of BPD with either laser (690 plus or minus 3 nm) or light-emitting diode (LED; 690 plus or minus 12 nm) light. Results indicated the equivalency of the two light sources in this test system, with LED light being slightly more efficient, due possibly to a fluence rate lower than laser light.

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Anna M. Richter, Ashok K. Jain, Alice J. Canaan, Howard Meadows, and Julia G. Levy "Skin photosensitivity as a model in photodynamic therapy", Proc. SPIE 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities, (31 January 1996); https://doi.org/10.1117/12.230986

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