Functionalized benzochlorins for PDT

Byron C. Robinson; Ricardo Orbegoso

doi:10.1117/12.237537

2 April 1996 Functionalized benzochlorins for PDT

Byron C. Robinson, Ricardo Orbegoso

Proceedings Volume 2675, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V; (1996) https://doi.org/10.1117/12.237537
Event: Photonics West '96, 1996, San Jose, CA, United States

Abstract

In order to evaluate structure-activity relationships in the benzochlorin ring system, a series of functionalized benzochlorins have been synthesized by modifying the sulfonic acid group of octaethylbenzochlorin sulfonic acid (OEBCS). Using very simple chemistry it has been possible to produce a large number of benzochlorins that differ only in the nature of functionality of a pendant side arm. The introduction of zinc or tin into the benzochlorin macrocycle produces the corresponding metallated benzochlorins that retain the original functionality. The synthesis and spectroscopic properties of the free base and metallobenzochlorins are discussed. Preliminary in vivo results show that different functionality causes significant differences in biological efficacy.

Citation Download Citation

Byron C. Robinson and Ricardo Orbegoso "Functionalized benzochlorins for PDT", Proc. SPIE 2675, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V, (2 April 1996); https://doi.org/10.1117/12.237537

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